If you're looking for another Nylas alternative, Ably offers a suite of APIs for real-time apps. It can handle live chat, broadcasting data and synchronizing data, and is used in EdTech and FinTech. Ably also offers high availability with a 99.999% uptime SLA and supports more than 25 client and server libraries, including React and PHP.
Another option is SignalWire, which offers a full communications platform with voice, messaging and video APIs. It's geared for contact centers, education and healthcare, with features like customizable voice assistants and powerful messaging. SignalWire promises high availability and low latency with its elastic cloud networks and real-time communication APIs.
If you're looking for something more geared toward relationship management, Clay could be a good alternative. It aggregates contact information from services like email and social media, and offers automated contact updates and smart prompts. Clay works on multiple devices and integrates with apps like Gmail and Google Calendar, so it could be useful for professionals who need to keep their relationships in order.